FIGURE

Fig. 5

ID

ZDB-FIG-060718-11

Publication

Asai et al., 2006 - Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear

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Fig. 5

The expression of fgf8 and sef genes in WT and atrophin2 knockdown embryos. (A) In a control embryo at 24 hpf, fgf8 transcripts are detected in the telencephalon, optic stalk, isthmus, otic vesicle, developing somites, and tail bud. (B) fgf8 is expressed more broadly in an atrophin2 knockdown embryo. (C) A 26-somite control embryo treated with sef probe displays prominent labeling of the optic cup and otic vesicle. (D) An atrophin2 knockdown embryo shows a similar pattern of labeling but more extensive expression than in control fish. (E) Quantitative PCR analysis confirms the increased expression of messages for fgf8, sef, and sprouty4 in atrophin2 knockdown animals; significance values were obtained with Student′s one-tailed t test. Control animals were injected with water. The error bars indicate standard deviations. (Scale bar: 100 μm.)

Expression Data

Genes:	fgf8a il17rd
Fish:	slc45a2^unspecified slc45a2^unspecified + MO1-rerea
Knockdown Reagent:	MO1-rerea
Anatomical Terms:	midbrain hindbrain boundary optic cup optic stalk otic vesicle somite tail bud telencephalon
Stage Range:	26+ somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA